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Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA. Russo AJ, et al. Nat Immunol. 2021 Feb;22(2):154-165. doi: 10.1038/s41590-020-00844-7. Epub 2021 Jan 4. Nat Immunol. 2021. PMID: 33398185 Free PMC article.
AIM2 in health and disease: Inflammasome and beyond.
Kumari P, Russo AJ, Shivcharan S, Rathinam VA. Kumari P, et al. Immunol Rev. 2020 Sep;297(1):83-95. doi: 10.1111/imr.12903. Epub 2020 Jul 26. Immunol Rev. 2020. PMID: 32713036 Free PMC article. Review.
Innate immunity to intracellular LPS.
Rathinam VAK, Zhao Y, Shao F. Rathinam VAK, et al. Nat Immunol. 2019 May;20(5):527-533. doi: 10.1038/s41590-019-0368-3. Epub 2019 Apr 8. Nat Immunol. 2019. PMID: 30962589 Free PMC article. Review.
Lipid Peroxidation Adds Fuel to Pyr(optosis).
Russo AJ, Rathinam VAK. Russo AJ, et al. Cell Host Microbe. 2018 Jul 11;24(1):8-9. doi: 10.1016/j.chom.2018.06.010. Cell Host Microbe. 2018. PMID: 30001526 Free article.