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Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Schiffers C, Lundblad LKA, Hristova M, Habibovic A, Dustin CM, Daphtary N, Aliyeva M, Seward DJ, Janssen-Heininger YMW, Wouters EFM, Reynaert NL, van der Vliet A. Schiffers C, et al. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L144-L158. doi: 10.1152/ajplung.00021.2021. Epub 2021 May 5. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33951398 Free PMC article.
Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells.
Aboushousha R, Elko E, Chia SB, Manuel AM, van de Wetering C, van der Velden J, MacPherson M, Erickson C, Reisz JA, D'Alessandro A, Wouters EFM, Reynaert NL, Lam YW, Anathy V, van der Vliet A, Seward DJ, Janssen-Heininger YMW. Aboushousha R, et al. FASEB J. 2021 May;35(5):e21525. doi: 10.1096/fj.202002687RR. FASEB J. 2021. PMID: 33817836 Free PMC article.
Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma.
Manuel AM, van de Wetering C, MacPherson M, Erickson C, Murray C, Aboushousha R, van der Velden J, Dixon AE, Poynter ME, Irvin CG, Taatjes DJ, van der Vliet A, Anathy V, Janssen-Heininger YMW. Manuel AM, et al. Am J Respir Cell Mol Biol. 2021 Jun;64(6):709-721. doi: 10.1165/rcmb.2020-0512OC. Am J Respir Cell Mol Biol. 2021. PMID: 33662229 Free PMC article.
Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN.
Veith C, Hristova M, Danyal K, Habibovic A, Dustin CM, McDonough JE, Vanaudenaerde BM, Kreuter M, Schneider MA, Kahn N, van Schooten FJ, Boots AW, van der Vliet A. Veith C, et al. Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L356-L367. doi: 10.1152/ajplung.00444.2019. Epub 2020 Dec 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33325804 Free PMC article.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Schiffers C, van de Wetering C, Bauer RA, Habibovic A, Hristova M, Dustin CM, Lambrichts S, Vacek PM, Wouters EF, Reynaert NL, van der Vliet A. Schiffers C, et al. JCI Insight. 2021 Jan 25;6(2):e142189. doi: 10.1172/jci.insight.142189. JCI Insight. 2021. PMID: 33301419 Free PMC article.
Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling.
Chia SB, Nolin JD, Aboushousha R, Erikson C, Irvin CG, Poynter ME, van der Velden J, Taatjes DJ, van der Vliet A, Anathy V, Janssen-Heininger YMW. Chia SB, et al. Redox Biol. 2020 Oct;37:101720. doi: 10.1016/j.redox.2020.101720. Epub 2020 Sep 14. Redox Biol. 2020. PMID: 32971362 Free PMC article.
21 results