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Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin.
J Gen Physiol. 2024 May 6;156(5):e202413538. doi: 10.1085/jgp.202413538. Epub 2024 Apr 12.
J Gen Physiol. 2024.
PMID: 38607351
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin.
Doran MH, Rynkiewicz MJ, Rasicci D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W.
Doran MH, et al.
J Gen Physiol. 2023 Mar 6;155(3):e202213267. doi: 10.1085/jgp.202213267. Epub 2023 Jan 12.
J Gen Physiol. 2023.
PMID: 36633586
Free PMC article.
Item in Clipboard
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation.
Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W.
Doran MH, et al.
J Gen Physiol. 2023 Feb 6;155(2):e202213274. doi: 10.1085/jgp.202213274. Epub 2022 Dec 2.
J Gen Physiol. 2023.
PMID: 36459134
Free PMC article.
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The Central Role of the F-Actin Surface in Myosin Force Generation.
Doran MH, Lehman W.
Doran MH, et al.
Biology (Basel). 2021 Nov 23;10(12):1221. doi: 10.3390/biology10121221.
Biology (Basel). 2021.
PMID: 34943138
Free PMC article.
Review.
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Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG.
Sewanan LR, et al.
J Gen Physiol. 2021 Sep 6;153(9):e202012640. doi: 10.1085/jgp.202012640. Epub 2021 Jul 28.
J Gen Physiol. 2021.
PMID: 34319370
Free PMC article.
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A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics.
Lehman W, Rynkiewicz MJ, Moore JR.
Lehman W, et al.
J Muscle Res Cell Motil. 2020 Mar;41(1):23-38. doi: 10.1007/s10974-019-09501-5. Epub 2019 Feb 15.
J Muscle Res Cell Motil. 2020.
PMID: 30771202
Free PMC article.
Review.
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