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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 15
1959 17
1960 19
1961 19
1962 23
1963 46
1964 62
1965 70
1966 180
1967 217
1968 217
1969 207
1970 212
1971 196
1972 211
1973 236
1974 301
1975 382
1976 427
1977 618
1978 998
1979 1214
1980 15706
1981 33548
1982 34574
1983 35046
1984 36750
1985 37475
1986 38661
1987 40090
1988 41227
1989 42819
1990 44951
1991 46221
1992 46797
1993 47548
1994 49131
1995 49504
1996 49716
1997 50031
1998 51059
1999 52550
2000 55150
2001 56514
2002 59596
2003 63828
2004 71599
2005 78208
2006 86895
2007 93401
2008 103546
2009 110327
2010 119718
2011 128873
2012 133492
2013 138653
2014 140136
2015 141278
2016 136514
2017 131631
2018 133990
2019 135044
2020 147470
2021 154003
2022 138870
2023 133552
2024 41906
2025 1

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3,268,086 results

Results by year

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Page 1
Prime editing-mediated correction of the leptin receptor in muscle cells of db/db mice.
Lee KE, Xu Y, Geng B, Kim J, Kellon N, He Z, Zhang Z, Li D, Gouchoe DA, Zhu H. Lee KE, et al. Biotechnol J. 2024 May;19(5):e2300676. doi: 10.1002/biot.202300676. Biotechnol J. 2024. PMID: 38730523
Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative approaches have been developed to cure monogenic genetic diseases, namely by genome editing. A specific type of genomic editing, prime …
Genetic diseases can be caused by monogenic diseases, which result from a single gene mutation in the DNA sequence. Many innovative a …
The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells.
Vicente JJ, Khan K, Tillinghast G, McFaline-Figueroa JL, Sancak Y, Stella N. Vicente JJ, et al. J Transl Med. 2024 May 10;22(1):441. doi: 10.1186/s12967-024-05234-3. J Transl Med. 2024. PMID: 38730481
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis and become malignant polyploid giant cancer …
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. S …
Differences in provider approach to initiating and titrating guideline directed medical therapy in heart failure with reduced ejection fraction.
Cordwin DJ, Guidi J, Alhashimi L, Hummel SL, Koelling TM, Dorsch MP. Cordwin DJ, et al. BMC Cardiovasc Disord. 2024 May 11;24(1):247. doi: 10.1186/s12872-024-03911-1. BMC Cardiovasc Disord. 2024. PMID: 38730379
METHODS: A survey containing 20 clinical vignettes of patients with HFrEF was answered by a national sample of 127 cardiologists and 68 internal/family medicine physicians. ...
METHODS: A survey containing 20 clinical vignettes of patients with HFrEF was answered by a national sample of 127 cardiologists and …
Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis.
Yew PY, Loth M, Adam TJ, Wolfson J, Liang Y, Tonellato PJ, Chi CL. Yew PY, et al. BMC Cardiovasc Disord. 2024 May 10;24(1):245. doi: 10.1186/s12872-024-03921-z. BMC Cardiovasc Disord. 2024. PMID: 38730371
METHODS: To evaluate the potential (long-term) impact of the 2013 ACC/AHA Guideline release in Nov 2013 in the U.S., we investigated the association of the 2013 ACC/AHA Guideline with the trend changes in 5-Year MACE survival and three other statin-related outcomes …
METHODS: To evaluate the potential (long-term) impact of the 2013 ACC/AHA Guideline release in Nov 2013 in the U.S., we invest …
Obesity and lipid indices as predictors of depressive symptoms in middle-aged and elderly Chinese: insights from a nationwide cohort study.
Zhang X, Wang Y, Yang X, Li Y, Gui J, Mei Y, Liu H, Guo LL, Li J, Lei Y, Li X, Sun L, Yang L, Yuan T, Wang C, Zhang D, Li J, Liu M, Hua Y, Zhang L. Zhang X, et al. BMC Psychiatry. 2024 May 10;24(1):351. doi: 10.1186/s12888-024-05806-z. BMC Psychiatry. 2024. PMID: 38730360
Therefore, we investigate the relationship and predictive ability of 13 obesity- and lipid-related indices with depressive symptoms among middle-aged and elderly Chinese. METHODS: The data were obtained from The China Health and Retirement Longitudinal Study (CHARLS). Our …
Therefore, we investigate the relationship and predictive ability of 13 obesity- and lipid-related indices with depressive symptoms among mi …
Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome.
Levy T, Gluckman J, Siper PM, Halpern D, Zweifach J, Filip-Dhima R, Holder JL Jr, Trelles MP, Johnson K, Bernstein JA, Berry-Kravis E, Powell CM, Soorya LV, Thurm A, Buxbaum JD, Sahin M, Kolevzon A, Srivastava S; Developmental Synaptopathies Consortium. Levy T, et al. J Neurodev Disord. 2024 May 10;16(1):25. doi: 10.1186/s11689-024-09541-0. J Neurodev Disord. 2024. PMID: 38730350
BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by SHANK3 haploinsufficiency and is associated with an increased risk for seizures. ...A larger cohort might be able to identify additional associations with medical features. Gen …
BACKGROUND: Phelan-McDermid syndrome (PMS) is a genetic neurodevelopmental disorder caused by SHANK3 haploinsufficiency and is associ …
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids.
Bloks NGC, Dicks A, Harissa Z, Nelissen RGHH, Hajmousa G, Ramos YFM, de Almeida RC, Guilak F, Meulenbelt I. Bloks NGC, et al. Clin Epigenetics. 2024 May 10;16(1):64. doi: 10.1186/s13148-024-01676-0. Clin Epigenetics. 2024. PMID: 38730337
BACKGROUND: Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors, such as genetics and age, hyper …
BACKGROUND: Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobi …
Discovery of LLC355 as an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1.
Liu L, Zhao L, Yang L, Chai M, Liu Z, Ma N, Wang Y, Wu Q, Guo J, Zhou F, Huang W, Ren X, Wang J, Ding M, Wang Z, Ding K. Liu L, et al. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00162. Online ahead of print. J Med Chem. 2024. PMID: 38730324
Compound LLC355 efficiently degraded DDR1 protein with a DC(50) value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. Mechanistic studies revealed compound LLC355 to induce DDR1 degradation via lysosome-mediated autophagy. Importantly, compound LLC355 poten …
Compound LLC355 efficiently degraded DDR1 protein with a DC(50) value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. …
3,268,086 results
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