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Protease inhibitors targeting coronavirus and filovirus entry.
Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R Jr, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Zhou Y, et al. Antiviral Res. 2015 Apr;116:76-84. doi: 10.1016/j.antiviral.2015.01.011. Epub 2015 Feb 7. Antiviral Res. 2015. PMID: 25666761 Free PMC article.
Filovirus entry.
Simmons G. Simmons G. Adv Exp Med Biol. 2013;790:83-94. doi: 10.1007/978-1-4614-7651-1_5. Adv Exp Med Biol. 2013. PMID: 23884587 Free PMC article. Review.
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.
Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S. Gierer S, et al. J Virol. 2013 May;87(10):5502-11. doi: 10.1128/JVI.00128-13. Epub 2013 Mar 6. J Virol. 2013. PMID: 23468491 Free PMC article.
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