R01 NS095257/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2015	2
2016	1
2017	2
2018	1
2019	4
2021	1
2023	1
2024	0

1

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW. Sampognaro PJ, et al. Mol Neurodegener. 2023 May 2;18(1):29. doi: 10.1186/s13024-023-00621-8. Mol Neurodegener. 2023. PMID: 37131250 Free PMC article.

2

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.

Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW. Mohan S, et al. Mol Neurodegener. 2021 Aug 3;16(1):51. doi: 10.1186/s13024-021-00472-1. Mol Neurodegener. 2021. PMID: 34344440 Free PMC article.

3

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. Butler VJ, et al. PLoS Genet. 2019 Aug 9;15(8):e1008295. doi: 10.1371/journal.pgen.1008295. eCollection 2019 Aug. PLoS Genet. 2019. PMID: 31398187 Free PMC article.

4

Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.

Butler VJ, Cortopassi WA, Gururaj S, Wang AL, Pierce OM, Jacobson MP, Kao AW. Butler VJ, et al. Biochemistry. 2019 Jun 11;58(23):2670-2674. doi: 10.1021/acs.biochem.9b00275. Epub 2019 May 24. Biochemistry. 2019. PMID: 31099551 Free PMC article.

5

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.

Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW. Butler VJ, et al. J Mol Biol. 2019 Mar 1;431(5):1038-1047. doi: 10.1016/j.jmb.2019.01.027. Epub 2019 Jan 25. J Mol Biol. 2019. PMID: 30690031 Free PMC article.

6

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport.

Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW. Butler VJ, et al. Hum Mol Genet. 2019 May 1;28(9):1498-1514. doi: 10.1093/hmg/ddy442. Hum Mol Genet. 2019. PMID: 30590647 Free PMC article.

7

The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.

Hsu TY, Butler VJ, Kao AW. Hsu TY, et al. Methods Mol Biol. 2018;1806:193-206. doi: 10.1007/978-1-4939-8559-3_14. Methods Mol Biol. 2018. PMID: 29956278

8

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Perry DC, et al. Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. Brain. 2017. PMID: 29053860 Free PMC article.

9

Progranulin, lysosomal regulation and neurodegenerative disease.

Kao AW, McKay A, Singh PP, Brunet A, Huang EJ. Kao AW, et al. Nat Rev Neurosci. 2017 Jun;18(6):325-333. doi: 10.1038/nrn.2017.36. Epub 2017 Apr 24. Nat Rev Neurosci. 2017. PMID: 28435163 Free PMC article. Review.

10

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH. Bettcher BM, et al. Alzheimers Dement (Amst). 2016 Jun 22;3:91-7. doi: 10.1016/j.dadm.2016.05.004. eCollection 2016. Alzheimers Dement (Amst). 2016. PMID: 27453930 Free PMC article.

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