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2009 2
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N-glycosylation is a potent regulator of prion protein neurotoxicity.
Schilling KM, Jorwal P, Ubilla-Rodriguez NC, Assafa TE, Gatdula JRP, Vultaggio JS, Harris DA, Millhauser GL. Schilling KM, et al. J Biol Chem. 2023 Sep;299(9):105101. doi: 10.1016/j.jbc.2023.105101. Epub 2023 Jul 27. J Biol Chem. 2023. PMID: 37507020 Free PMC article.
Mechanisms of prion-induced toxicity.
Mercer RCC, Harris DA. Mercer RCC, et al. Cell Tissue Res. 2023 Apr;392(1):81-96. doi: 10.1007/s00441-022-03683-0. Epub 2022 Sep 7. Cell Tissue Res. 2023. PMID: 36070155 Review.
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M. Linsenmeier L, et al. Sci Adv. 2021 Nov 26;7(48):eabj1826. doi: 10.1126/sciadv.abj1826. Epub 2021 Nov 24. Sci Adv. 2021. PMID: 34818048 Free PMC article.
Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR.
McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. McDonald AJ, et al. Structure. 2019 Jun 4;27(6):907-922.e5. doi: 10.1016/j.str.2019.03.008. Epub 2019 Apr 4. Structure. 2019. PMID: 30956132 Free PMC article.
Prion neurotoxicity.
Le NTT, Wu B, Harris DA. Le NTT, et al. Brain Pathol. 2019 Mar;29(2):263-277. doi: 10.1111/bpa.12694. Epub 2019 Jan 17. Brain Pathol. 2019. PMID: 30588688 Free PMC article. Review.
36 results