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The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.
Flores AJ, Bartlett MJ, Root BK, Parent KL, Heien ML, Porreca F, Polt R, Sherman SJ, Falk T. Flores AJ, et al. Neuropharmacology. 2018 Oct;141:260-271. doi: 10.1016/j.neuropharm.2018.09.005. Epub 2018 Sep 7. Neuropharmacology. 2018. PMID: 30201210 Free PMC article.
CNS active O-linked glycopeptides.
Jones EM, Polt R. Jones EM, et al. Front Chem. 2015 Jun 24;3:40. doi: 10.3389/fchem.2015.00040. eCollection 2015. Front Chem. 2015. PMID: 26157795 Free PMC article. Review.
Structural Requirements for CNS Active Opioid Glycopeptides.
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Lefever M, et al. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26125201
15 results