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Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms.
Cell Mol Life Sci. 2024 Feb 27;81(1):105. doi: 10.1007/s00018-024-05121-6.
Cell Mol Life Sci. 2024.
PMID: 38413417
Free PMC article.
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.
Rawat R, Tunc-Ozcan E, McGuire TL, Peng CY, Kessler JA.
Rawat R, et al.
Nat Commun. 2022 May 12;13(1):2650. doi: 10.1038/s41467-022-30386-5.
Nat Commun. 2022.
PMID: 35551462
Free PMC article.
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Hippocampal BMP signaling as a common pathway for antidepressant action.
Tunc-Ozcan E, Brooker SM, Bonds JA, Tsai YH, Rawat R, McGuire TL, Peng CY, Kessler JA.
Tunc-Ozcan E, et al.
Cell Mol Life Sci. 2021 Dec 22;79(1):31. doi: 10.1007/s00018-021-04026-y.
Cell Mol Life Sci. 2021.
PMID: 34936033
Free PMC article.
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Activating newborn neurons suppresses depression and anxiety-like behaviors.
Tunc-Ozcan E, Peng CY, Zhu Y, Dunlop SR, Contractor A, Kessler JA.
Tunc-Ozcan E, et al.
Nat Commun. 2019 Aug 21;10(1):3768. doi: 10.1038/s41467-019-11641-8.
Nat Commun. 2019.
PMID: 31434877
Free PMC article.
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Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment.
Brooker SM, Gobeske KT, Chen J, Peng CY, Kessler JA.
Brooker SM, et al.
Mol Psychiatry. 2017 Jun;22(6):910-919. doi: 10.1038/mp.2016.160. Epub 2016 Oct 4.
Mol Psychiatry. 2017.
PMID: 27698430
Free PMC article.
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