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Page 1
Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage.
Arnhold V, Chang WY, Jansen SA, Thangavelu G, Calafiore M, Vinci P, Fu YY, Ito T, Takashima S, Egorova A, Kuttiyara J, Perlstein A, van Hoesel M, Liu C, Blazar BR, Lindemans CA, Hanash AM. Arnhold V, et al. J Clin Invest. 2024 Feb 13;134(7):e155880. doi: 10.1172/JCI155880. J Clin Invest. 2024. PMID: 38349762 Free PMC article.
Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse.
DeWolf S, Elhanati Y, Nichols K, Waters NR, Nguyen CL, Slingerland JB, Rodriguez N, Lyudovyk O, Giardina PA, Kousa AI, Andrlová H, Ceglia N, Fei T, Kappagantula R, Li Y, Aleynick N, Baez P, Murali R, Hayashi A, Lee N, Gipson B, Rangesa M, Katsamakis Z, Dai A, Blouin AG, Arcila M, Masilionis I, Chaligne R, Ponce DM, Landau HJ, Politikos I, Tamari R, Hanash AM, Jenq RR, Giralt SA, Markey KA, Zhang Y, Perales MA, Socci ND, Greenbaum BD, Iacobuzio-Donahue CA, Hollmann TJ, van den Brink MRM, Peled JU. DeWolf S, et al. Sci Transl Med. 2023 Jul 26;15(706):eabq0476. doi: 10.1126/scitranslmed.abq0476. Epub 2023 Jul 26. Sci Transl Med. 2023. PMID: 37494469 Free PMC article.
A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract.
Ponce DM, Alousi AM, Nakamura R, Slingerland J, Calafiore M, Sandhu KS, Barker JN, Devlin S, Shia J, Giralt S, Perales MA, Moore G, Fatmi S, Soto C, Gomes A, Giardina P, Marcello L, Yan X, Tang T, Dreyer K, Chen J, Daley WL, Peled JU, van den Brink MRM, Hanash AM. Ponce DM, et al. Blood. 2023 Mar 23;141(12):1389-1401. doi: 10.1182/blood.2021015111. Blood. 2023. PMID: 36399701 Free PMC article. Clinical Trial.
T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage.
Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, Chandra D, O'Connor MH, Mertelsmann AM, Vinci P, Kuttiyara J, Devlin SM, Middendorp S, Calafiore M, Egorova A, Kleppe M, Lo Y, Shroyer NF, Cheng EH, Levine RL, Liu C, Kolesnick R, Lindemans CA, Hanash AM. Takashima S, et al. Sci Immunol. 2019 Dec 6;4(42):eaay8556. doi: 10.1126/sciimmunol.aay8556. Sci Immunol. 2019. PMID: 31811055 Free PMC article.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM. Tsai JJ, et al. Blood. 2018 Dec 27;132(26):2763-2774. doi: 10.1182/blood-2017-10-812941. Epub 2018 Oct 31. Blood. 2018. PMID: 30381375 Free PMC article.