R01 HL142604/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2017	2
2018	1
2019	2
2020	7
2021	2
2023	2
2024	0

1

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

Sparkenbaugh EM, Henderson MW, Miller-Awe M, Abrams C, Ilich A, Trebak F, Ramadas N, Vital S, Bohinc D, Bane KL, Chen C, Patel M, Wallisch M, Renné T, Gruber A, Cooley B, Gailani D, Kasztan M, Vercellotti GM, Belcher JD, Gavins FE, Stavrou EX, Key NS, Pawlinski R. Sparkenbaugh EM, et al. Blood. 2023 Apr 13;141(15):1871-1883. doi: 10.1182/blood.2022017074. Blood. 2023. PMID: 36706361 Free PMC article.

2

Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis.

Liao YE, Xu Y, Arnold K, Zhang F, Li J, Sellers R, Yin C, Pagadala V, Inman AM, Linhardt RJ, Xu D, Pawlinski R, Liu J. Liao YE, et al. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209528120. doi: 10.1073/pnas.2209528120. Epub 2023 Jan 17. Proc Natl Acad Sci U S A. 2023. PMID: 36649428 Free PMC article.

3

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.

Henderson MW, Sparkenbaugh EM, Wang S, Ilich A, Noubouossie DF, Mailer R, Renné T, Flick MJ, Luyendyk JP, Chen ZL, Strickland S, Stravitz RT, McCrae KR, Key NS, Pawlinski R. Henderson MW, et al. Blood. 2021 Jul 22;138(3):259-272. doi: 10.1182/blood.2020006198. Blood. 2021. PMID: 33827130 Free PMC article.

4

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease.

Ansari J, Senchenkova EY, Vital SA, Al-Yafeai Z, Kaur G, Sparkenbaugh EM, Orr AW, Pawlinski R, Hebbel RP, Granger DN, Kubes P, Gavins FNE. Ansari J, et al. Blood. 2021 Mar 18;137(11):1538-1549. doi: 10.1182/blood.2020009166. Blood. 2021. PMID: 33512489 Free PMC article.

5

Synthetic anticoagulant heparan sulfate attenuates liver ischemia reperfusion injury.

Arnold K, Xu Y, Liao YE, Cooley BC, Pawlinski R, Liu J. Arnold K, et al. Sci Rep. 2020 Oct 14;10(1):17187. doi: 10.1038/s41598-020-74275-7. Sci Rep. 2020. PMID: 33057098 Free PMC article.

6

Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage.

Li J, Sparkenbaugh EM, Su G, Zhang F, Xu Y, Xia K, He P, Baytas S, Pechauer S, Padmanabhan A, Linhardt RJ, Pawlinski R, Liu J. Li J, et al. ACS Cent Sci. 2020 Jul 22;6(7):1199-1207. doi: 10.1021/acscentsci.0c00712. Epub 2020 Jul 1. ACS Cent Sci. 2020. PMID: 32724854 Free PMC article.

7

High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease.

Sparkenbaugh EM, Kasztan M, Henderson MW, Ellsworth P, Davis PR, Wilson KJ, Reeves B, Key NS, Strickland S, McCrae K, Pollock DM, Pawlinski R. Sparkenbaugh EM, et al. J Thromb Haemost. 2020 Sep;18(9):2329-2340. doi: 10.1111/jth.14972. Epub 2020 Aug 27. J Thromb Haemost. 2020. PMID: 32573897 Free PMC article.

8

Using heparin molecules to manage COVID-2019.

Liu J, Li J, Arnold K, Pawlinski R, Key NS. Liu J, et al. Res Pract Thromb Haemost. 2020 Jun 9;4(4):518-523. doi: 10.1002/rth2.12353. eCollection 2020 May. Res Pract Thromb Haemost. 2020. PMID: 32542212 Free PMC article. Review.

9

Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure.

Arnold K, Xu Y, Sparkenbaugh EM, Li M, Han X, Zhang X, Xia K, Piegore M, Zhang F, Zhang X, Henderson M, Pagadala V, Su G, Tan L, Park PW, Stravitz RT, Key NS, Linhardt RJ, Pawlinski R, Xu D, Liu J. Arnold K, et al. Sci Transl Med. 2020 Mar 18;12(535):eaav8075. doi: 10.1126/scitranslmed.aav8075. Sci Transl Med. 2020. PMID: 32188725 Free PMC article.

10

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease.

Sparkenbaugh EM, Chen C, Brzoska T, Nguyen J, Wang S, Vercellotti GM, Key NS, Sundd P, Belcher JD, Pawlinski R. Sparkenbaugh EM, et al. Blood. 2020 May 14;135(20):1783-1787. doi: 10.1182/blood.2019003543. Blood. 2020. PMID: 31977004 Free PMC article.

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