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MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis.
Del Rosario O, Suresh K, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Del Rosario O, et al. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L700-L711. doi: 10.1152/ajplung.00340.2022. Epub 2023 Mar 28. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36976920 Free PMC article.
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer.
Suresh K, Del Rosario O, Kallem M, Singh G, Shah A, Zheng L, Yun X, Philip NM, Putcha N, McClure MB, Jiang H, D'Alessio F, Srivastava M, Bera A, Shimoda LA, Merchant M, Rane MJ, Machamer CE, Mock J, Hagan R, Koch AL, Punjabi NM, Kolb TM, Damarla M. Suresh K, et al. Physiol Genomics. 2023 Apr 1;55(4):168-178. doi: 10.1152/physiolgenomics.00155.2022. Epub 2023 Mar 6. Physiol Genomics. 2023. PMID: 36878491 Free PMC article.
A nonapoptotic endothelial barrier-protective role for caspase-3.
Suresh K, Carino K, Johnston L, Servinsky L, Machamer CE, Kolb TM, Lam H, Dudek SM, An SS, Rane MJ, Shimoda LA, Damarla M. Suresh K, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1118-L1126. doi: 10.1152/ajplung.00487.2018. Epub 2019 Mar 25. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30908935 Free PMC article.