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Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Kathiriya JJ, et al. Nat Cell Biol. 2022 Jan;24(1):10-23. doi: 10.1038/s41556-021-00809-4. Epub 2021 Dec 30. Nat Cell Biol. 2022. PMID: 34969962 Free PMC article.
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.
Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Wang C, et al. J Clin Invest. 2018 Oct 1;128(10):4343-4358. doi: 10.1172/JCI99435. Epub 2018 Jul 12. J Clin Invest. 2018. PMID: 29999500 Free PMC article.
Extracellular matrix in lung development, homeostasis and disease.
Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Zhou Y, et al. Matrix Biol. 2018 Nov;73:77-104. doi: 10.1016/j.matbio.2018.03.005. Epub 2018 Mar 8. Matrix Biol. 2018. PMID: 29524630 Free PMC article. Review.