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Cardiac gene therapy.
Chaanine AH, Kalman J, Hajjar RJ. Chaanine AH, et al. Semin Thorac Cardiovasc Surg. 2010 Summer;22(2):127-39. doi: 10.1053/j.semtcvs.2010.09.009. Semin Thorac Cardiovasc Surg. 2010. PMID: 21092890 Free PMC article. Review.
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy.
Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Peña JR, et al. J Mol Cell Cardiol. 2010 Dec;49(6):993-1002. doi: 10.1016/j.yjmcc.2010.09.010. Epub 2010 Sep 18. J Mol Cell Cardiol. 2010. PMID: 20854827 Free PMC article.
Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.
Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B, Borow K, Dittrich H, Zsebo KM, Hajjar RJ; Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators. Jaski BE, et al. J Card Fail. 2009 Apr;15(3):171-81. doi: 10.1016/j.cardfail.2009.01.013. J Card Fail. 2009. PMID: 19327618 Free PMC article. Clinical Trial.
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.
Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Tschope C, Pieske B, Lebeche D, Schultheiss HP, Hajjar RJ, Poller WC. Suckau L, et al. Circulation. 2009 Mar 10;119(9):1241-52. doi: 10.1161/CIRCULATIONAHA.108.783852. Epub 2009 Feb 23. Circulation. 2009. PMID: 19237664 Free PMC article.