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Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Mol Cell. 2022 Sep 1;82(17):3299-3311.e8. doi: 10.1016/j.molcel.2022.06.026. Epub 2022 Jul 21.
Mol Cell. 2022.
PMID: 35868311
Free PMC article.
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth.
Schrötter S, Yuskaitis CJ, MacArthur MR, Mitchell SJ, Hosios AM, Osipovich M, Torrence ME, Mitchell JR, Hoxhaj G, Sahin M, Manning BD.
Schrötter S, et al.
Cell Rep. 2022 May 17;39(7):110824. doi: 10.1016/j.celrep.2022.110824.
Cell Rep. 2022.
PMID: 35584673
Free PMC article.
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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G.
Soflaee MH, et al.
Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z.
Nat Commun. 2022.
PMID: 35577785
Free PMC article.
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Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival.
Kim D, Hoxhaj G.
Kim D, et al.
Mol Cell. 2022 May 5;82(9):1613-1615. doi: 10.1016/j.molcel.2022.04.018.
Mol Cell. 2022.
PMID: 35523127
Free article.
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