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2022 2
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USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma.
Mallard HJ, Wan S, Nidhi P, Hanscom-Trofy YD, Mohapatra B, Woods NT, Lopez-Guerrero JA, Llombart-Bosch A, Machado I, Scotlandi K, Kreiling NF, Perry MC, Mirza S, Coulter DW, Band V, Band H, Ghosal G. Mallard HJ, et al. Mol Cancer Res. 2023 Nov 1;21(11):1186-1204. doi: 10.1158/1541-7786.MCR-23-0323. Mol Cancer Res. 2023. PMID: 37478161 Free PMC article.
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Chakraborty S, Bhat AM, Mushtaq I, Luan H, Kalluchi A, Mirza S, Storck MD, Chaturvedi N, Lopez-Guerrero JA, Llombart-Bosch A, Machado I, Scotlandi K, Meza JL, Ghosal G, Coulter DW, Rowley JM, Band V, Mohapatra BC, Band H. Chakraborty S, et al. bioRxiv [Preprint]. 2023 Mar 22:2023.01.15.524130. doi: 10.1101/2023.01.15.524130. bioRxiv. 2023. PMID: 36711452 Free PMC article. Updated. Preprint.
Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Napoleon JV, Sagar S, Kubica SP, Boghean L, Kour S, King HM, Sonawane YA, Crawford AJ, Gautam N, Kizhake S, Bialk PA, Kmiec E, Mallareddy JR, Patil PP, Rana S, Singh S, Prahlad J, Grandgenett PM, Borgstahl GEO, Ghosal G, Alnouti Y, Hollingsworth MA, Radhakrishnan P, Natarajan A. Napoleon JV, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119. doi: 10.1073/pnas.2115071119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476515 Free PMC article.