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Table representation of search results timeline featuring number of search results per year.
Year | Number of Results |
---|---|
2021 | 3 |
2022 | 1 |
2023 | 2 |
2024 | 1 |
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6 results
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Page 1
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1.
Nat Commun. 2024.
PMID: 38580648
Free PMC article.
Promoter-independent synthesis of chemically modified RNA by human DNA polymerase θ variants.
Tredinnick T, Kent T, Minakhin L, Li Z, Madzo J, Chen XS, Pomerantz RT.
Tredinnick T, et al.
RNA. 2023 Aug;29(8):1288-1300. doi: 10.1261/rna.079396.122. Epub 2023 Apr 27.
RNA. 2023.
PMID: 37105714
Item in Clipboard
Polλ promotes microhomology-mediated end-joining.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT.
Chandramouly G, et al.
Nat Struct Mol Biol. 2023 Jan;30(1):107-114. doi: 10.1038/s41594-022-00895-4. Epub 2022 Dec 19.
Nat Struct Mol Biol. 2023.
PMID: 36536104
Free PMC article.
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DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity.
Chen XS, Pomerantz RT.
Chen XS, et al.
Genes (Basel). 2021 Jul 27;12(8):1146. doi: 10.3390/genes12081146.
Genes (Basel). 2021.
PMID: 34440316
Free PMC article.
Review.
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Polθ reverse transcribes RNA and promotes RNA-templated DNA repair.
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT.
Chandramouly G, et al.
Sci Adv. 2021 Jun 11;7(24):eabf1771. doi: 10.1126/sciadv.abf1771. Print 2021 Jun.
Sci Adv. 2021.
PMID: 34117057
Free PMC article.
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Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining.
Chandramouly G, Liao S, Rusanov T, Borisonnik N, Calbert ML, Kent T, Sullivan-Reed K, Vekariya U, Kashkina E, Skorski T, Yan H, Pomerantz RT.
Chandramouly G, et al.
Cell Rep. 2021 Mar 9;34(10):108820. doi: 10.1016/j.celrep.2021.108820.
Cell Rep. 2021.
PMID: 33691100
Free PMC article.
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