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Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Lemberg KM, Ali ES, Krecmerova M, Aguilar JMH, Alt J, Peters DE, Zhao L, Wu Y, Nuha N, Asara JM, Staedtke V, Pratilas CA, Majer P, Rais R, Ben-Sahra I, Slusher BS. Lemberg KM, et al. Mol Cancer Ther. 2023 Dec 1;22(12):1390-1403. doi: 10.1158/1535-7163.MCT-23-0258. Mol Cancer Ther. 2023. PMID: 37616542 Free PMC article.
GATOR2 rings GATOR1 to speak to mTORC1.
Sahu U, Ben-Sahra I. Sahu U, et al. Mol Cell. 2023 Jan 5;83(1):6-8. doi: 10.1016/j.molcel.2022.12.011. Mol Cell. 2023. PMID: 36608671 Free PMC article.
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Soflaee MH, et al. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. Nat Commun. 2022. PMID: 35577785 Free PMC article.
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.
Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU. Shireman JM, et al. Brain. 2021 May 7;144(4):1230-1246. doi: 10.1093/brain/awab020. Brain. 2021. PMID: 33855339 Free PMC article.
12 results