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Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Cohen-Sharir Y, McFarland JM, Abdusamad M, Marquis C, Bernhard SV, Kazachkova M, Tang H, Ippolito MR, Laue K, Zerbib J, Malaby HLH, Jones A, Stautmeister LM, Bockaj I, Wardenaar R, Lyons N, Nagaraja A, Bass AJ, Spierings DCJ, Foijer F, Beroukhim R, Santaguida S, Golub TR, Stumpff J, Storchová Z, Ben-David U. Cohen-Sharir Y, et al. Nature. 2021 Feb;590(7846):486-491. doi: 10.1038/s41586-020-03114-6. Epub 2021 Jan 27. Nature. 2021. PMID: 33505028 Free PMC article.
The mechanism of kinesin inhibition by kinesin-binding protein.
Atherton J, Hummel JJ, Olieric N, Locke J, Peña A, Rosenfeld SS, Steinmetz MO, Hoogenraad CC, Moores CA. Atherton J, et al. Elife. 2020 Nov 30;9:e61481. doi: 10.7554/eLife.61481. Elife. 2020. PMID: 33252036 Free PMC article.
The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J. Bodrug T, et al. Elife. 2020 Jan 20;9:e51131. doi: 10.7554/eLife.51131. Elife. 2020. PMID: 31958056 Free PMC article.