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Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Bertholet AM, et al. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. Nature. 2022. PMID: 35614225 Free PMC article.
H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. Bertholet AM, et al. Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24. Nature. 2019. PMID: 31341297 Free PMC article.
UCP1: A transporter for H+ and fatty acid anions.
Bertholet AM, Kirichok Y. Bertholet AM, et al. Biochimie. 2017 Mar;134:28-34. doi: 10.1016/j.biochi.2016.10.013. Epub 2016 Oct 27. Biochimie. 2017. PMID: 27984203 Free PMC article. Review.
Perinatal Licensing of Thermogenesis by IL-33 and ST2.
Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. Odegaard JI, et al. Cell. 2016 Aug 11;166(4):841-854. doi: 10.1016/j.cell.2016.06.040. Epub 2016 Jul 21. Cell. 2016. PMID: 27453471 Free PMC article.