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Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.
Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR. Chennamadhavuni D, et al. Cell Chem Biol. 2018 May 17;25(5):571-584.e8. doi: 10.1016/j.chembiol.2018.02.009. Epub 2018 Mar 22. Cell Chem Biol. 2018. PMID: 29576533 Free PMC article.
Contact sensitizers trigger human CD1-autoreactive T-cell responses.
Betts RJ, Perkovic A, Mahapatra S, Del Bufalo A, Camara K, Howell AR, Martinozzi Teissier S, De Libero G, Mori L. Betts RJ, et al. Eur J Immunol. 2017 Jul;47(7):1171-1180. doi: 10.1002/eji.201746939. Epub 2017 May 23. Eur J Immunol. 2017. PMID: 28440548 Free PMC article.
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.
Le Nours J, Praveena T, Pellicci DG, Gherardin NA, Ross FJ, Lim RT, Besra GS, Keshipeddy S, Richardson SK, Howell AR, Gras S, Godfrey DI, Rossjohn J, Uldrich AP. Le Nours J, et al. Nat Commun. 2016 Feb 15;7:10570. doi: 10.1038/ncomms10570. Nat Commun. 2016. PMID: 26875526 Free PMC article.
Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.
Birkholz A, Nemčovič M, Yu ED, Girardi E, Wang J, Khurana A, Pauwels N, Farber E, Chitale S, Franck RW, Tsuji M, Howell A, Van Calenbergh S, Kronenberg M, Zajonc DM. Birkholz A, et al. J Biol Chem. 2015 Jul 10;290(28):17206-17. doi: 10.1074/jbc.M115.654814. Epub 2015 May 27. J Biol Chem. 2015. PMID: 26018083 Free PMC article.
The molecular bases of δ/αβ T cell-mediated antigen recognition.
Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI. Pellicci DG, et al. J Exp Med. 2014 Dec 15;211(13):2599-615. doi: 10.1084/jem.20141764. Epub 2014 Dec 1. J Exp Med. 2014. PMID: 25452463 Free PMC article.
Synthesis of a 2"-deoxy-β-GalCer.
Thakur MS, Khurana A, Kronenberg M, Howell AR. Thakur MS, et al. Molecules. 2014 Jul 10;19(7):10090-102. doi: 10.3390/molecules190710090. Molecules. 2014. PMID: 25014535 Free PMC article.
Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.
Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR. Tyznik AJ, et al. Chem Biol. 2011 Dec 23;18(12):1620-30. doi: 10.1016/j.chembiol.2011.10.015. Chem Biol. 2011. PMID: 22195564 Free PMC article.
14 results