R01 GM083118/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2009	2
2010	1
2011	9
2012	6
2013	6
2014	3
2015	5
2016	6
2017	9
2018	8
2019	7
2020	4
2021	4
2022	2
2023	2
2024	0

1

Constrained catecholamines gain β₂AR selectivity through allosteric effects on pocket dynamics.

Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Xu X, et al. Nat Commun. 2023 Apr 14;14(1):2138. doi: 10.1038/s41467-023-37808-y. Nat Commun. 2023. PMID: 37059717 Free PMC article.

2

Time-resolved cryo-EM of G protein activation by a GPCR.

Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. bioRxiv [Preprint]. 2023 Mar 21:2023.03.20.533387. doi: 10.1101/2023.03.20.533387. bioRxiv. 2023. PMID: 36993214 Free PMC article. Updated. Preprint.

3

Non-canonical β-adrenergic activation of ERK at endosomes.

Kwon Y, Mehta S, Clark M, Walters G, Zhong Y, Lee HN, Sunahara RK, Zhang J. Kwon Y, et al. Nature. 2022 Nov;611(7934):173-179. doi: 10.1038/s41586-022-05343-3. Epub 2022 Oct 26. Nature. 2022. PMID: 36289326 Free PMC article.

4

Leveraging nonstructural data to predict structures and affinities of protein-ligand complexes.

Paggi JM, Belk JA, Hollingsworth SA, Villanueva N, Powers AS, Clark MJ, Chemparathy AG, Tynan JE, Lau TK, Sunahara RK, Dror RO. Paggi JM, et al. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2112621118. doi: 10.1073/pnas.2112621118. Proc Natl Acad Sci U S A. 2021. PMID: 34921117 Free PMC article.

5

Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor-Mutant Neoplasms.

Wheeler EC, Vora S, Mayer D, Kotini AG, Olszewska M, Park SS, Guccione E, Teruya-Feldstein J, Silverman L, Sunahara RK, Yeo GW, Papapetrou EP. Wheeler EC, et al. Cancer Discov. 2022 Mar 1;12(3):836-855. doi: 10.1158/2159-8290.CD-21-0508. Cancer Discov. 2022. PMID: 34620690 Free PMC article.

6

A photoswitchable GPCR-based opsin for presynaptic inhibition.

Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW 4th, Bruchas MR. Copits BA, et al. Neuron. 2021 Jun 2;109(11):1791-1809.e11. doi: 10.1016/j.neuron.2021.04.026. Epub 2021 May 11. Neuron. 2021. PMID: 33979635 Free PMC article.

7

Delineating the conformational landscape of the adenosine A_2A receptor during G protein coupling.

Huang SK, Pandey A, Tran DP, Villanueva NL, Kitao A, Sunahara RK, Sljoka A, Prosser RS. Huang SK, et al. Cell. 2021 Apr 1;184(7):1884-1894.e14. doi: 10.1016/j.cell.2021.02.041. Epub 2021 Mar 19. Cell. 2021. PMID: 33743210 Free PMC article.

8

Binding pathway determines norepinephrine selectivity for the human β₁AR over β₂AR.

Xu X, Kaindl J, Clark MJ, Hübner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X. Xu X, et al. Cell Res. 2021 May;31(5):569-579. doi: 10.1038/s41422-020-00424-2. Epub 2020 Oct 22. Cell Res. 2021. PMID: 33093660 Free PMC article.

9

Structural insights into differences in G protein activation by family A and family B GPCRs.

Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK. Hilger D, et al. Science. 2020 Jul 31;369(6503):eaba3373. doi: 10.1126/science.aba3373. Science. 2020. PMID: 32732395 Free PMC article.

10

Structure and selectivity engineering of the M₁ muscarinic receptor toxin complex.

Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK. Maeda S, et al. Science. 2020 Jul 10;369(6500):161-167. doi: 10.1126/science.aax2517. Science. 2020. PMID: 32646996 Free PMC article.

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