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2022 4
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Page 1
Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk.
Celis K, Moreno MDMM, Rajabli F, Whitehead P, Hamilton-Nelson K, Dykxhoorn DM, Nuytemans K, Wang L, Flanagan M, Weintraub S, Geula C, Gearing M, Dalgard CL, Jin F, Bennett DA, Schuck T, Pericak-Vance MA, Griswold AJ, Young JI, Vance JM. Celis K, et al. Alzheimers Dement. 2023 Sep;19(9):3902-3915. doi: 10.1002/alz.13075. Epub 2023 Apr 10. Alzheimers Dement. 2023. PMID: 37037656
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
Rajabli F, Beecham GW, Hendrie HC, Baiyewu O, Ogunniyi A, Gao S, Kushch NA, Lipkin-Vasquez M, Hamilton-Nelson KL, Young JI, Dykxhoorn DM, Nuytemans K, Kunkle BW, Wang L, Jin F, Liu X, Feliciano-Astacio BE; Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium; Schellenberg GD, Dalgard CL, Griswold AJ, Byrd GS, Reitz C, Cuccaro ML, Haines JL, Pericak-Vance MA, Vance JM. Rajabli F, et al. PLoS Genet. 2022 Jul 5;18(7):e1009977. doi: 10.1371/journal.pgen.1009977. eCollection 2022 Jul. PLoS Genet. 2022. PMID: 35788729 Free PMC article.
53BP1 regulates heterochromatin through liquid phase separation.
Zhang L, Geng X, Wang F, Tang J, Ichida Y, Sharma A, Jin S, Chen M, Tang M, Pozo FM, Wang W, Wang J, Wozniak M, Guo X, Miyagi M, Jin F, Xu Y, Yao X, Zhang Y. Zhang L, et al. Nat Commun. 2022 Jan 18;13(1):360. doi: 10.1038/s41467-022-28019-y. Nat Commun. 2022. PMID: 35042897 Free PMC article.
Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.
Nuytemans K, Lipkin Vasquez M, Wang L, Van Booven D, Griswold AJ, Rajabli F, Celis K, Oron O, Hofmann N, Rolati S, Garcia-Serje C, Zhang S, Jin F, Argenziano M, Grant SFA, Chesi A, Brown CD, Young JI, Dykxhoorn DM, Pericak-Vance MA, Vance JM. Nuytemans K, et al. Alzheimers Dement. 2022 Oct;18(10):1930-1942. doi: 10.1002/alz.12534. Epub 2022 Jan 3. Alzheimers Dement. 2022. PMID: 34978147 Free PMC article.