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Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Salimando GJ, et al. Nat Commun. 2023 Sep 13;14(1):5632. doi: 10.1038/s41467-023-41407-2. Nat Commun. 2023. PMID: 37704594 Free PMC article.
GIP receptor agonism blocks chemotherapy-induced nausea and vomiting.
Borner T, Reiner BC, Crist RC, Furst CD, Doebley SA, Halas JG, Ai M, Samms RJ, De Jonghe BC, Hayes MR. Borner T, et al. Mol Metab. 2023 Jul;73:101743. doi: 10.1016/j.molmet.2023.101743. Epub 2023 May 26. Mol Metab. 2023. PMID: 37245848 Free PMC article.
Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.
Asker M, Krieger JP, Liles A, Tinsley IC, Borner T, Maric I, Doebley S, Furst CD, Börchers S, Longo F, Bhat YR, De Jonghe BC, Hayes MR, Doyle RP, Skibicka KP. Asker M, et al. Diabetes Obes Metab. 2023 Mar;25(3):856-877. doi: 10.1111/dom.14937. Epub 2023 Jan 9. Diabetes Obes Metab. 2023. PMID: 36495318 Free PMC article.