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The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults.
Nakhe AY, Dadi PK, Kim J, Dickerson MT, Behera S, Dobson JR, Shrestha S, Cartailler JP, Sampson L, Magnuson MA, Jacobson DA. Nakhe AY, et al. bioRxiv [Preprint]. 2024 Feb 27:2023.06.20.545631. doi: 10.1101/2023.06.20.545631. bioRxiv. 2024. PMID: 37546831 Free PMC article. Updated. Preprint.
IP3Rs puff along: A SNAPpy dance with IP3 and Ca2.
Nakhe AY, Jacobson DA. Nakhe AY, et al. J Biol Chem. 2023 Mar;299(3):103010. doi: 10.1016/j.jbc.2023.103010. Epub 2023 Feb 10. J Biol Chem. 2023. PMID: 36773801 Free PMC article.
Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function.
Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Thapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J, Piemonti L, de Koning E, Leclerc I, Bouzakri K, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez A. Cheung R, et al. Diabetes. 2022 Jul 1;71(7):1525-1545. doi: 10.2337/db21-0803. Diabetes. 2022. PMID: 35476777 Free PMC article.