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Cancer Therapy-Related Hypertension: A Scientific Statement From the American Heart Association.
Cohen JB, Brown NJ, Brown SA, Dent S, van Dorst DCH, Herrmann SM, Lang NN, Oudit GY, Touyz RM; American Heart Association Council on Hypertension; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on the Kidney in Cardiovascular Disease. Cohen JB, et al. Hypertension. 2023 Mar;80(3):e46-e57. doi: 10.1161/HYP.0000000000000224. Epub 2023 Jan 9. Hypertension. 2023. PMID: 36621810 Free PMC article. Review.
The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells.
Mashayekhi M, Wanjalla CN, Warren CM, Simmons JD, Ghoshal K, Pilkinton M, Bailin SS, Gabriel CL, Pozzi A, Koethe JR, Brown NJ, Kalams SA, Luther JM. Mashayekhi M, et al. Prostaglandins Other Lipid Mediat. 2022 Feb;158:106604. doi: 10.1016/j.prostaglandins.2021.106604. Epub 2021 Dec 15. Prostaglandins Other Lipid Mediat. 2022. PMID: 34922004 Free PMC article.
GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans.
Luther JM, Ray J, Wei D, Koethe JR, Hannah L, DeMatteo A, Manning R, Terker AS, Peng D, Nian H, Yu C, Mashayekhi M, Gamboa J, Brown NJ. Luther JM, et al. Hypertension. 2021 Sep;78(4):1092-1102. doi: 10.1161/HYPERTENSIONAHA.121.17659. Epub 2021 Aug 30. Hypertension. 2021. PMID: 34455816 Free PMC article. Clinical Trial.