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Page 1
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.
Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Gaspar RC, et al. Diabetologia. 2023 Mar;66(3):567-578. doi: 10.1007/s00125-022-05838-8. Epub 2022 Dec 1. Diabetologia. 2023. PMID: 36456864
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.
Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Habtemichael EN, et al. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8. Nat Metab. 2021. PMID: 33686286 Free PMC article.
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
Lyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI. Lyu K, et al. Cell Metab. 2020 Oct 6;32(4):654-664.e5. doi: 10.1016/j.cmet.2020.08.001. Epub 2020 Sep 2. Cell Metab. 2020. PMID: 32882164 Free PMC article.
20 results