R01 DK092111/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R01 DK092111/DK/NIDDK NIH HHS/United States[Grant - PubMed

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Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury.

Khandekar G, Llewellyn J, Kriegermeier A, Waisbourd-Zinman O, Johnson N, Du Y, Giwa R, Liu X, Kisseleva T, Russo PA, Theise ND, Wells RG. Khandekar G, et al. J Hepatol. 2020 Jan;72(1):135-145. doi: 10.1016/j.jhep.2019.08.036. Epub 2019 Sep 25. J Hepatol. 2020. PMID: 31562906 Free PMC article.

Biliary Atresia: Clinical and Research Challenges for the Twenty-First Century.

Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ. Bezerra JA, et al. Hepatology. 2018 Sep;68(3):1163-1173. doi: 10.1002/hep.29905. Hepatology. 2018. PMID: 29604222 Free PMC article. Review.

Modeling intestinal disorders using zebrafish.

Zhao X, Pack M. Zhao X, et al. Methods Cell Biol. 2017;138:241-270. doi: 10.1016/bs.mcb.2016.11.006. Epub 2017 Jan 7. Methods Cell Biol. 2017. PMID: 28129846 Review.

Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish.

Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M. Zhao X, et al. Hepatology. 2016 Sep;64(3):894-907. doi: 10.1002/hep.28603. Epub 2016 Jun 11. Hepatology. 2016. PMID: 27102575 Free PMC article.

The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17.

Waisbourd-Zinman O, Koh H, Tsai S, Lavrut PM, Dang C, Zhao X, Pack M, Cave J, Hawes M, Koo KA, Porter JR, Wells RG. Waisbourd-Zinman O, et al. Hepatology. 2016 Sep;64(3):880-93. doi: 10.1002/hep.28599. Epub 2016 May 20. Hepatology. 2016. PMID: 27081925 Free PMC article.

Reactivity of Biliatresone, a Natural Biliary Toxin, with Glutathione, Histamine, and Amino Acids.

Koo KA, Waisbourd-Zinman O, Wells RG, Pack M, Porter JR. Koo KA, et al. Chem Res Toxicol. 2016 Feb 15;29(2):142-9. doi: 10.1021/acs.chemrestox.5b00308. Epub 2016 Jan 13. Chem Res Toxicol. 2016. PMID: 26713899 Free PMC article.

Biliatresone, a Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone.

Koo KA, Lorent K, Gong W, Windsor P, Whittaker SJ, Pack M, Wells RG, Porter JR. Koo KA, et al. Chem Res Toxicol. 2015 Aug 17;28(8):1519-21. doi: 10.1021/acs.chemrestox.5b00227. Epub 2015 Jul 20. Chem Res Toxicol. 2015. PMID: 26175131 Free PMC article.

Identification of a plant isoflavonoid that causes biliary atresia.

Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, Pack M. Lorent K, et al. Sci Transl Med. 2015 May 6;7(286):286ra67. doi: 10.1126/scitranslmed.aaa1652. Sci Transl Med. 2015. PMID: 25947162 Free PMC article.

Isolation of neonatal extrahepatic cholangiocytes.

Karjoo S, Wells RG. Karjoo S, et al. J Vis Exp. 2014 Jun 5;(88):51621. doi: 10.3791/51621. J Vis Exp. 2014. PMID: 24961407 Free PMC article.

A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from zebrafish liver.

Wilkins BJ, Gong W, Pack M. Wilkins BJ, et al. Gene Expr Patterns. 2014 Mar;14(2):62-8. doi: 10.1016/j.gep.2013.12.002. Epub 2014 Jan 3. Gene Expr Patterns. 2014. PMID: 24394404 Free PMC article.

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