R01 DK062306/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2005	1
2006	2
2007	1
2008	1
2009	1
2010	1
2011	1
2012	1
2013	4
2014	3
2015	1
2016	2
2017	1
2018	3
2019	4
2024	0

1

Real-time hyperpolarized ¹³C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4-double knockout mouse livers.

Sharma G, Wu CY, Wynn RM, Gui W, Malloy CR, Sherry AD, Chuang DT, Khemtong C. Sharma G, et al. Sci Rep. 2019 Nov 11;9(1):16480. doi: 10.1038/s41598-019-52952-6. Sci Rep. 2019. PMID: 31712597 Free PMC article.

2

Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure.

Chen M, Gao C, Yu J, Ren S, Wang M, Wynn RM, Chuang DT, Wang Y, Sun H. Chen M, et al. J Am Heart Assoc. 2019 Jun 4;8(11):e011625. doi: 10.1161/JAHA.118.011625. Epub 2019 Jun 1. J Am Heart Assoc. 2019. PMID: 31433721 Free PMC article.

3

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

Zhou M, Shao J, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H. Zhou M, et al. Diabetes. 2019 Sep;68(9):1730-1746. doi: 10.2337/db18-0927. Epub 2019 Jun 5. Diabetes. 2019. PMID: 31167878 Free PMC article.

4

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma.

Suh EH, Hackett EP, Wynn RM, Chuang DT, Zhang B, Luo W, Sherry AD, Park JM. Suh EH, et al. Sci Rep. 2019 Jan 23;9(1):340. doi: 10.1038/s41598-018-37390-0. Sci Rep. 2019. PMID: 30674979 Free PMC article.

5

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. White PJ, et al. Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17. Cell Metab. 2018. PMID: 29779826 Free PMC article.

6

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.

Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang DT, Merritt ME. Wu CY, et al. J Biol Chem. 2018 Jun 22;293(25):9604-9613. doi: 10.1074/jbc.RA118.002838. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739849 Free PMC article.

7

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.

Wu CY, Tso SC, Chuang JL, Gui WJ, Lou M, Sharma G, Khemtong C, Qi X, Wynn RM, Chuang DT. Wu CY, et al. Mol Metab. 2018 Jun;12:12-24. doi: 10.1016/j.molmet.2018.03.014. Epub 2018 Mar 31. Mol Metab. 2018. PMID: 29656110 Free PMC article.

8

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT. Tso SC, et al. J Med Chem. 2017 Feb 9;60(3):1142-1150. doi: 10.1021/acs.jmedchem.6b01540. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28085286 Free PMC article.

9

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation.

Perez-Siles G, Ly C, Grant A, Drew AP, Yiu EM, Ryan MM, Chuang DT, Tso SC, Nicholson GA, Kennerson ML. Perez-Siles G, et al. Neurobiol Dis. 2016 Oct;94:237-44. doi: 10.1016/j.nbd.2016.07.001. Epub 2016 Jul 5. Neurobiol Dis. 2016. PMID: 27388934

10

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.

Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. Sun H, et al. Circulation. 2016 May 24;133(21):2038-49. doi: 10.1161/CIRCULATIONAHA.115.020226. Epub 2016 Apr 8. Circulation. 2016. PMID: 27059949 Free PMC article.

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