R01 DK052962/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2001	1
2002	1
2005	3
2006	1
2009	1
2010	1
2011	2
2012	1
2013	2
2014	3
2015	2
2016	3
2017	2
2018	1
2021	1
2024	0

1

Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.

Pace BS, Perrine S, Li B, Makala L, Xu H, Takezaki M, Wolf RF, Wang A, Xu X, Huang J, Alimardanov A, Tawa GJ, Sangerman J, Faller A, Zheng W, Toney L, Haugabook SJ. Pace BS, et al. Blood Cells Mol Dis. 2021 Jul;89:102561. doi: 10.1016/j.bcmd.2021.102561. Epub 2021 Mar 12. Blood Cells Mol Dis. 2021. PMID: 33744514 Free PMC article.

2

The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease.

DiMartino LD, Baumann AA, Hsu LL, Kanter J, Gordeuk VR, Glassberg J, Treadwell MJ, Melvin CL, Telfair J, Klesges LM, King A, Wun T, Shah N, Gibson RW, Hankins JS; Sickle Cell Disease Implementation Consortium. DiMartino LD, et al. Am J Hematol. 2018 Dec;93(12):E391-E395. doi: 10.1002/ajh.25282. Epub 2018 Oct 17. Am J Hematol. 2018. PMID: 30203558 Free PMC article. No abstract available.

3

An oral Hemokine^TM, α-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo.

Faller DV, Castaneda SA, Zhou D, Vedamony M, Newburger PE, White GL, Kosanke S, Plett PA, Orschell CM, Boosalis MS, Perrine SP. Faller DV, et al. Blood Cells Mol Dis. 2017 Mar;63:1-8. doi: 10.1016/j.bcmd.2016.10.021. Epub 2016 Oct 31. Blood Cells Mol Dis. 2017. PMID: 27888688 Free PMC article.

4

Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer.

Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Dai Y, et al. Am J Hematol. 2017 Jan;92(1):E10-E11. doi: 10.1002/ajh.24590. Epub 2016 Nov 18. Am J Hematol. 2017. PMID: 27766663 Free PMC article. No abstract available.

5

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice.

Boosalis MS, Sangerman JI, White GL, Wolf RF, Shen L, Dai Y, White E, Makala LH, Li B, Pace BS, Nouraie M, Faller DV, Perrine SP. Boosalis MS, et al. PLoS One. 2015 Dec 29;10(12):e0144660. doi: 10.1371/journal.pone.0144660. eCollection 2015. PLoS One. 2015. PMID: 26713848 Free PMC article.

6

Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.

Dai Y, Sangerman J, Luo HY, Fucharoen S, Chui DH, Faller DV, Perrine SP. Dai Y, et al. Blood Cells Mol Dis. 2016 Jan;56(1):62-9. doi: 10.1016/j.bcmd.2015.10.004. Epub 2015 Oct 27. Blood Cells Mol Dis. 2016. PMID: 26603726 Free PMC article.

7

A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.

Patthamalai P, Fuchareon S, Chaneiam N, Ghalie RG, Chui DH, Boosalis MS, Perrine SP. Patthamalai P, et al. Blood. 2014 Mar 20;123(12):1956-7. doi: 10.1182/blood-2013-11-538470. Blood. 2014. PMID: 24652964 Free PMC article. Clinical Trial. No abstract available.

8

Targeted fetal hemoglobin induction for treatment of beta hemoglobinopathies.

Perrine SP, Pace BS, Faller DV. Perrine SP, et al. Hematol Oncol Clin North Am. 2014 Apr;28(2):233-48. doi: 10.1016/j.hoc.2013.11.009. Hematol Oncol Clin North Am. 2014. PMID: 24589264 Review.

9

A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia.

Inati A, Kahale M, Perrine SP, Chui DH, Taher AT, Koussa S, Abi Nasr T, Abbas HA, Ghalie RG. Inati A, et al. Br J Haematol. 2014 Feb;164(3):456-8. doi: 10.1111/bjh.12635. Epub 2013 Nov 13. Br J Haematol. 2014. PMID: 24224649 Free PMC article. Clinical Trial. No abstract available.

10

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.

Fucharoen S, Inati A, Siritanaratku N, Thein SL, Wargin WC, Koussa S, Taher A, Chaneim N, Boosalis M, Berenson R, Perrine SP. Fucharoen S, et al. Br J Haematol. 2013 May;161(4):587-93. doi: 10.1111/bjh.12304. Epub 2013 Mar 27. Br J Haematol. 2013. PMID: 23530969 Free PMC article. Clinical Trial.

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