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2012 2
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74 results

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Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.
In situ identification of cellular drug targets in mammalian tissue.
Pang Z, Schafroth MA, Ogasawara D, Wang Y, Nudell V, Lal NK, Yang D, Wang K, Herbst DM, Ha J, Guijas C, Blankman JL, Cravatt BF, Ye L. Pang Z, et al. Cell. 2022 May 12;185(10):1793-1805.e17. doi: 10.1016/j.cell.2022.03.040. Epub 2022 Apr 27. Cell. 2022. PMID: 35483372 Free PMC article.
Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease.
Ruiz-Pérez G, Ruiz de Martín Esteban S, Marqués S, Aparicio N, Grande MT, Benito-Cuesta I, Martínez-Relimpio AM, Arnanz MA, Tolón RM, Posada-Ayala M, Cravatt BF, Esteban JA, Romero J, Palenzuela R. Ruiz-Pérez G, et al. J Neuroinflammation. 2021 Sep 29;18(1):223. doi: 10.1186/s12974-021-02276-y. J Neuroinflammation. 2021. PMID: 34587978 Free PMC article.
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.
Rong J, Mori W, Xia X, Schafroth MA, Zhao C, Van RS, Yamasaki T, Chen J, Xiao Z, Haider A, Ogasawara D, Hiraishi A, Shao T, Zhang Y, Chen Z, Pang F, Hu K, Xie L, Fujinaga M, Kumata K, Gou Y, Fang Y, Gu S, Wei H, Bao L, Xu H, Collier TL, Shao Y, Carson RE, Cravatt BF, Wang L, Zhang MR, Liang SH. Rong J, et al. J Med Chem. 2021 Oct 14;64(19):14283-14298. doi: 10.1021/acs.jmedchem.1c00747. Epub 2021 Sep 27. J Med Chem. 2021. PMID: 34569803 Free PMC article.
Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex.
Pavón FJ, Polis IY, Stouffer DG, Cravatt BF, Roberto M, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH, Serrano A. Pavón FJ, et al. Neurobiol Stress. 2021 Jan 9;14:100293. doi: 10.1016/j.ynstr.2021.100293. eCollection 2021 May. Neurobiol Stress. 2021. PMID: 33490317 Free PMC article.
ABHD4-dependent developmental anoikis safeguards the embryonic brain.
László ZI, Lele Z, Zöldi M, Miczán V, Mógor F, Simon GM, Mackie K, Kacskovics I, Cravatt BF, Katona I. László ZI, et al. Nat Commun. 2020 Aug 31;11(1):4363. doi: 10.1038/s41467-020-18175-4. Nat Commun. 2020. PMID: 32868797 Free PMC article.
74 results