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Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Chen Q, et al. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. J Med Chem. 2023. PMID: 36724486 Free PMC article.
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Orth-He EL, et al. Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649711 Free PMC article.
The NLRP1 and CARD8 inflammasomes detect reductive stress.
Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA. Wang Q, et al. Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649710 Free PMC article.
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.
Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, Bachovchin DA. Ball DP, et al. Sci Immunol. 2022 Nov 11;7(77):eabm7200. doi: 10.1126/sciimmunol.abm7200. Epub 2022 Nov 4. Sci Immunol. 2022. PMID: 36332009 Free PMC article.