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Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.
Wang M, Li W, Tomimatsu N, Yu CH, Ji JH, Alejo S, Witus SR, Alimbetov D, Fitzgerald O, Wu B, Wang Q, Huang Y, Gan Y, Dong F, Kwon Y, Sareddy GR, Curiel TJ, Habib AA, Hromas R, Dos Santos Passos C, Yao T, Ivanov DN, Brzovic PS, Burma S, Klevit RE, Zhao W. Wang M, et al. Mol Cell. 2023 Oct 19;83(20):3679-3691.e8. doi: 10.1016/j.molcel.2023.09.015. Epub 2023 Oct 4. Mol Cell. 2023. PMID: 37797621
BRCA1/BARD1 is a nucleosome reader and writer.
Witus SR, Zhao W, Brzovic PS, Klevit RE. Witus SR, et al. Trends Biochem Sci. 2022 Jul;47(7):582-595. doi: 10.1016/j.tibs.2022.03.001. Epub 2022 Mar 26. Trends Biochem Sci. 2022. PMID: 35351360 Free PMC article. Review.
The BRCA1/BARD1 ubiquitin ligase and its substrates.
Witus SR, Stewart MD, Klevit RE. Witus SR, et al. Biochem J. 2021 Sep 30;478(18):3467-3483. doi: 10.1042/BCJ20200864. Biochem J. 2021. PMID: 34591954 Free PMC article. Review.