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Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.
Dong H, He X, Zhang L, Chen W, Lin YC, Liu SB, Wang H, Nguyen LXT, Li M, Zhu Y, Zhao D, Ghoda L, Serody J, Vincent B, Luznik L, Gojo I, Zeidner J, Su R, Chen J, Sharma R, Pirrotte P, Wu X, Hu W, Han W, Shen B, Kuo YH, Jin J, Salhotra A, Wang J, Marcucci G, Luo YL, Li L. Dong H, et al. Nat Cancer. 2024 Apr;5(4):601-624. doi: 10.1038/s43018-024-00736-x. Epub 2024 Feb 27. Nat Cancer. 2024. PMID: 38413714 Free PMC article.
TET2 deficiency promotes MDS-associated leukemogenesis.
Huang F, Sun J, Chen W, Zhang L, He X, Dong H, Wu Y, Wang H, Li Z, Ball B, Khaled S, Marcucci G, Li L. Huang F, et al. Blood Cancer J. 2022 Oct 4;12(10):141. doi: 10.1038/s41408-022-00739-w. Blood Cancer J. 2022. PMID: 36195586 Free PMC article. No abstract available.
Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade.
Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. Wang H, et al. Blood. 2022 Jun 30;139(26):3752-3770. doi: 10.1182/blood.2021015108. Blood. 2022. PMID: 35439288 Free PMC article.
HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML.
Huang F, Sun J, Chen W, He X, Zhu Y, Dong H, Wang H, Li Z, Zhang L, Khaled S, Marcucci G, Huang J, Li L. Huang F, et al. Aging (Albany NY). 2020 Jul 29;12(17):16759-16774. doi: 10.18632/aging.103605. Epub 2020 Jul 29. Aging (Albany NY). 2020. PMID: 32726753 Free PMC article.