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CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis.
Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. Minami JK, et al. Cancer Cell. 2023 Jun 12;41(6):1048-1060.e9. doi: 10.1016/j.ccell.2023.05.001. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236196 Free article.
EGFR, the Lazarus target for precision oncology in glioblastoma.
Lin B, Ziebro J, Smithberger E, Skinner KR, Zhao E, Cloughesy TF, Binder ZA, O'Rourke DM, Nathanson DA, Furnari FB, Miller CR. Lin B, et al. Neuro Oncol. 2022 Dec 1;24(12):2035-2062. doi: 10.1093/neuonc/noac204. Neuro Oncol. 2022. PMID: 36125064 Free PMC article. Review.
Metabolic Vulnerabilities in Brain Cancer.
Morrow D, Minami J, Nathanson DA. Morrow D, et al. Neurosurg Clin N Am. 2021 Apr;32(2):159-169. doi: 10.1016/j.nec.2020.12.006. Neurosurg Clin N Am. 2021. PMID: 33781499 Review.
Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.
Oughourlian TC, Yao J, Hagiwara A, Nathanson DA, Raymond C, Pope WB, Salamon N, Lai A, Ji M, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. Oughourlian TC, et al. Neuroradiology. 2021 Jun;63(6):857-868. doi: 10.1007/s00234-020-02585-8. Epub 2020 Oct 26. Neuroradiology. 2021. PMID: 33106922 Free PMC article.