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In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift.
Kheirolomoom A, Kare AJ, Ingham ES, Paulmurugan R, Robinson ER, Baikoghli M, Inayathullah M, Seo JW, Wang J, Fite BZ, Wu B, Tumbale SK, Raie MN, Cheng RH, Nichols L, Borowsky AD, Ferrara KW. Kheirolomoom A, et al. Biomaterials. 2022 Feb;281:121339. doi: 10.1016/j.biomaterials.2021.121339. Epub 2021 Dec 29. Biomaterials. 2022. PMID: 35078042 Free PMC article.
Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy.
Zhang H, Tang WL, Kheirolomoom A, Fite BZ, Wu B, Lau K, Baikoghli M, Raie MN, Tumbale SK, Foiret J, Ingham ES, Mahakian LM, Tam SM, Cheng RH, Borowsky AD, Ferrara KW. Zhang H, et al. J Control Release. 2021 Feb 10;330:1080-1094. doi: 10.1016/j.jconrel.2020.11.013. Epub 2020 Nov 13. J Control Release. 2021. PMID: 33189786 Free PMC article.
Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites.
Ilovitsh T, Feng Y, Foiret J, Kheirolomoom A, Zhang H, Ingham ES, Ilovitsh A, Tumbale SK, Fite BZ, Wu B, Raie MN, Zhang N, Kare AJ, Chavez M, Qi LS, Pelled G, Gazit D, Vermesh O, Steinberg I, Gambhir SS, Ferrara KW. Ilovitsh T, et al. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12674-12685. doi: 10.1073/pnas.1914906117. Epub 2020 May 19. Proc Natl Acad Sci U S A. 2020. PMID: 32430322 Free PMC article.
Immune-mediated ECM depletion improves tumour perfusion and payload delivery.
Yeow YL, Kotamraju VR, Wang X, Chopra M, Azme N, Wu J, Schoep TD, Delaney DS, Feindel K, Li J, Kennedy KM, Allen WM, Kennedy BF, Larma I, Sampson DD, Mahakian LM, Fite BZ, Zhang H, Friman T, Mann AP, Aziz FA, Kumarasinghe MP, Johansson M, Ee HC, Yeoh G, Mou L, Ferrara KW, Billiran H, Ganss R, Ruoslahti E, Hamzah J. Yeow YL, et al. EMBO Mol Med. 2019 Dec;11(12):e10923. doi: 10.15252/emmm.201910923. Epub 2019 Nov 11. EMBO Mol Med. 2019. PMID: 31709774 Free PMC article.
32 results