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Year Number of Results
2016 1
2017 8
2018 7
2019 4
2020 5
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2023 1
2024 0

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Page 1
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.
Damayanti NP, Saadatzadeh MR, Dobrota E, Ordaz JD, Bailey BJ, Pandya PH, Bijangi-Vishehsaraei K, Shannon HE, Alfonso A, Coy K, Trowbridge M, Sinn AL, Zhang ZY, Gallagher RI, Wulfkuhle J, Petricoin E, Richardson AM, Marshall MS, Lion A, Ferguson MJ, Balsara KE, Pollok KE. Damayanti NP, et al. Sci Rep. 2023 Jun 6;13(1):9163. doi: 10.1038/s41598-023-36107-2. Sci Rep. 2023. PMID: 37280243 Free PMC article.
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Gebregiworgis T, Kano Y, St-Germain J, Radulovich N, Udaskin ML, Mentes A, Huang R, Poon BPK, He W, Valencia-Sama I, Robinson CM, Huestis M, Miao J, Yeh JJ, Zhang ZY, Irwin MS, Lee JE, Tsao MS, Raught B, Marshall CB, Ohh M, Ikura M. Gebregiworgis T, et al. Nat Commun. 2021 Nov 1;12(1):6274. doi: 10.1038/s41467-021-26526-y. Nat Commun. 2021. PMID: 34725361 Free PMC article.
Systemic inhibition of PTPN22 augments anticancer immunity.
Ho WJ, Croessmann S, Lin J, Phyo ZH, Charmsaz S, Danilova L, Mohan AA, Gross NE, Chen F, Dong J, Aggarwal D, Bai Y, Wang J, He J, Leatherman JM, Yarchoan M, Armstrong TD, Zaidi N, Fertig EJ, Denny JC, Park BH, Zhang ZY, Jaffee EM. Ho WJ, et al. J Clin Invest. 2021 Jul 20;131(17):e146950. doi: 10.1172/JCI146950. Online ahead of print. J Clin Invest. 2021. PMID: 34283806 Free PMC article.
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.
Zhu G, Xie J, Kong W, Xie J, Li Y, Du L, Zheng Q, Sun L, Guan M, Li H, Zhu T, He H, Liu Z, Xia X, Kan C, Tao Y, Shen HC, Li D, Wang S, Yu Y, Yu ZH, Zhang ZY, Liu C, Zhu J. Zhu G, et al. Cell. 2020 Oct 15;183(2):490-502.e18. doi: 10.1016/j.cell.2020.09.002. Epub 2020 Sep 30. Cell. 2020. PMID: 33002410 Free PMC article.
29 results