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Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies.
Mod Pathol. 2022 Nov;35(11):1702-1712. doi: 10.1038/s41379-022-01124-5. Epub 2022 Jul 7.
Mod Pathol. 2022.
PMID: 35798968
Free PMC article.
Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.
Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH.
Aguilar M, et al.
J Pathol. 2021 May;254(1):20-30. doi: 10.1002/path.5628. Epub 2021 Mar 9.
J Pathol. 2021.
PMID: 33506979
Free PMC article.
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Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.
Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH.
Cuevas IC, et al.
Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25880-25890. doi: 10.1073/pnas.1911310116. Epub 2019 Nov 26.
Proc Natl Acad Sci U S A. 2019.
PMID: 31772025
Free PMC article.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.
Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA.
Aguilera KY, et al.
Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1.
Mol Cancer Ther. 2017.
PMID: 28864681
Free PMC article.
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ.
Kim J, et al.
Nature. 2017 Jun 1;546(7656):168-172. doi: 10.1038/nature22359. Epub 2017 May 24.
Nature. 2017.
PMID: 28538732
Free PMC article.
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LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.
Peña CG, Castrillón DH.
Peña CG, et al.
Adv Exp Med Biol. 2017;943:211-241. doi: 10.1007/978-3-319-43139-0_7.
Adv Exp Med Biol. 2017.
PMID: 27910069
Review.
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LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment.
Peña CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH.
Peña CG, et al.
J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28.
J Clin Invest. 2015.
PMID: 26413869
Free PMC article.
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