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CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.
Thakkar PV, Kita K, Castillo UD, Galletti G, Madhukar N, Navarro EV, Barasoain I, Goodson HV, Sackett D, Díaz JF, Lu Y, RoyChoudhury A, Molina H, Elemento O, Shah MA, Giannakakou P. Thakkar PV, et al. Dev Cell. 2021 Dec 6;56(23):3264-3275.e7. doi: 10.1016/j.devcel.2021.09.023. Epub 2021 Oct 20. Dev Cell. 2021. PMID: 34672971 Free PMC article.
Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer.
Galletti G, Zhang C, Gjyrezi A, Cleveland K, Zhang J, Powell S, Thakkar PV, Betel D, Shah MA, Giannakakou P. Galletti G, et al. Clin Cancer Res. 2020 Jul 15;26(14):3771-3783. doi: 10.1158/1078-0432.CCR-19-3018. Epub 2020 Apr 22. Clin Cancer Res. 2020. PMID: 32321717 Free PMC article. Clinical Trial.
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