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Year Number of Results
2010 1
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2013 3
2014 9
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2020 2
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29 results

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Page 1
TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs.
Parnandi N, Rendo V, Cui G, Botuyan MV, Remisova M, Nguyen H, Drané P, Beroukhim R, Altmeyer M, Mer G, Chowdhury D. Parnandi N, et al. Mol Cell. 2021 Jun 17;81(12):2583-2595.e6. doi: 10.1016/j.molcel.2021.03.039. Epub 2021 May 6. Mol Cell. 2021. PMID: 33961797 Free PMC article.
Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial.
Konstantinopoulos PA, Cheng SC, Wahner Hendrickson AE, Penson RT, Schumer ST, Doyle LA, Lee EK, Kohn EC, Duska LR, Crispens MA, Olawaiye AB, Winer IS, Barroilhet LM, Fu S, McHale MT, Schilder RJ, Färkkilä A, Chowdhury D, Curtis J, Quinn RS, Bowes B, D'Andrea AD, Shapiro GI, Matulonis UA. Konstantinopoulos PA, et al. Lancet Oncol. 2020 Jul;21(7):957-968. doi: 10.1016/S1470-2045(20)30180-7. Epub 2020 Jun 15. Lancet Oncol. 2020. PMID: 32553118 Free PMC article. Clinical Trial.
A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1.
Zheng XF, Acharya SS, Choe KN, Nikhil K, Adelmant G, Satapathy SR, Sharma S, Viccaro K, Rana S, Natarajan A, Sicinski P, Marto JA, Shah K, Chowdhury D. Zheng XF, et al. Nat Commun. 2019 Sep 18;10(1):4252. doi: 10.1038/s41467-019-12084-x. Nat Commun. 2019. PMID: 31534152 Free PMC article.
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D. He YJ, et al. Nature. 2018 Nov;563(7732):522-526. doi: 10.1038/s41586-018-0670-5. Epub 2018 Oct 31. Nature. 2018. PMID: 30464262 Free PMC article.
Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G. Botuyan MV, et al. Nat Struct Mol Biol. 2018 Jul;25(7):591-600. doi: 10.1038/s41594-018-0083-z. Epub 2018 Jul 2. Nat Struct Mol Biol. 2018. PMID: 29967538 Free PMC article.
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.
Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D. Drané P, et al. Nature. 2017 Mar 9;543(7644):211-216. doi: 10.1038/nature21358. Epub 2017 Feb 27. Nature. 2017. PMID: 28241136 Free PMC article.
29 results