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ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer.
Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, Diolaiti D, Papagiannakopoulos TY, Lyssiotis CA, Simeone DM. Purohit V, et al. Genes Dev. 2021 Feb 1;35(3-4):218-233. doi: 10.1101/gad.344184.120. Epub 2021 Jan 14. Genes Dev. 2021. PMID: 33446568 Free PMC article.
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM. Wang L, et al. Genes Dev. 2019 Jun 1;33(11-12):641-655. doi: 10.1101/gad.323303.118. Epub 2019 May 2. Genes Dev. 2019. PMID: 31048544 Free PMC article.
ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.
Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM. Wang L, et al. Genes Dev. 2015 Jan 15;29(2):171-83. doi: 10.1101/gad.253591.114. Genes Dev. 2015. PMID: 25593307 Free PMC article.
Outlier kinase expression by RNA sequencing as targets for precision therapy.
Kothari V, Wei I, Shankar S, Kalyana-Sundaram S, Wang L, Ma LW, Vats P, Grasso CS, Robinson DR, Wu YM, Cao X, Simeone DM, Chinnaiyan AM, Kumar-Sinha C. Kothari V, et al. Cancer Discov. 2013 Mar;3(3):280-93. doi: 10.1158/2159-8290.CD-12-0336. Epub 2013 Feb 5. Cancer Discov. 2013. PMID: 23384775 Free PMC article.
12 results