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Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Kanovsky M, Michl J, Botzolaki G, Morin J, Kovac C, Chung DL, Chie L, Friedman FK, Pincus MR. Kanovsky M, et al. Cancer Chemother Pharmacol. 2003 Sep;52(3):202-8. doi: 10.1007/s00280-003-0639-3. Epub 2003 May 29. Cancer Chemother Pharmacol. 2003. PMID: 12783204
Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.
Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, Rubinstein P, Visser J, Robinson R, Brandt-Rauf PW, Michl J, Fine RL, Pincus MR. Kanovsky M, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438-43. doi: 10.1073/pnas.211280698. Epub 2001 Oct 16. Proc Natl Acad Sci U S A. 2001. PMID: 11606716 Free PMC article.
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