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Year Number of Results
2018 2
2019 1
2020 1
2021 2
2022 4
2023 5
2024 1

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16 results

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Page 1
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP. Lei Y, et al. Cell. 2023 Jul 6;186(14):3013-3032.e22. doi: 10.1016/j.cell.2023.05.039. Epub 2023 Jun 22. Cell. 2023. PMID: 37352855 Free article.
Mitochondrial DNA Release in Innate Immune Signaling.
Newman LE, Shadel GS. Newman LE, et al. Annu Rev Biochem. 2023 Jun 20;92:299-332. doi: 10.1146/annurev-biochem-032620-104401. Epub 2023 Mar 31. Annu Rev Biochem. 2023. PMID: 37001140 Free article. Review.
Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis.
Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Nassour J, et al. Nature. 2023 Feb;614(7949):767-773. doi: 10.1038/s41586-023-05710-8. Epub 2023 Feb 8. Nature. 2023. PMID: 36755096 Free PMC article.
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.
Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. Cobo I, et al. Immunity. 2022 Aug 9;55(8):1386-1401.e10. doi: 10.1016/j.immuni.2022.06.022. Epub 2022 Aug 4. Immunity. 2022. PMID: 35931086 Free PMC article.
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions.
Hepokoski ML, Odish M, Lam MT, Coufal NG, Rolfsen ML, Shadel GS, Moyzis AG, Sainz AG, Takiar PG, Patel S, Leonard AJ, Samandari N, Hansen E, Trescott S, Nguyen C, Jepsen K, Cutter G, Gillespie MN, Spragg RG, Sasik R, Ix JH. Hepokoski ML, et al. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L84-L92. doi: 10.1152/ajplung.00128.2022. Epub 2022 Jun 14. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35699291 Free PMC article.
16 results