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Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens.
bioRxiv [Preprint]. 2023 Sep 21:2023.06.26.546596. doi: 10.1101/2023.06.26.546596.
bioRxiv. 2023.
PMID: 37425702
Free PMC article.
Preprint.
A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance.
Heithoff DM, Mahan SP, Barnes V L, Leyn SA, George CX, Zlamal JE, Limwongyut J, Bazan GC, Fried JC, Fitzgibbons LN, House JK, Samuel CE, Osterman AL, Low DA, Mahan MJ.
Heithoff DM, et al.
EBioMedicine. 2023 Mar;89:104461. doi: 10.1016/j.ebiom.2023.104461. Epub 2023 Feb 15.
EBioMedicine. 2023.
PMID: 36801104
Free PMC article.
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