R01 AI150451/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	5
2020	9
2021	4
2024	0

1

Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.

Bowen NE, Temple J, Shepard C, Oo A, Arizaga F, Kapoor-Vazirani P, Persaud M, Yu CH, Kim DH, Schinazi RF, Ivanov DN, Diaz-Griffero F, Yu DS, Xiong Y, Kim B. Bowen NE, et al. J Biol Chem. 2021 Oct;297(4):101170. doi: 10.1016/j.jbc.2021.101170. Epub 2021 Sep 4. J Biol Chem. 2021. PMID: 34492268 Free PMC article.

2

Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma Treatment.

Bothou C, Sharma A, Oo A, Kim B, Perge P, Igaz P, Ronchi CL, Shapiro I, Hantel C. Bothou C, et al. Cancers (Basel). 2021 Aug 20;13(16):4200. doi: 10.3390/cancers13164200. Cancers (Basel). 2021. PMID: 34439352 Free PMC article.

3

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells.

Martinat C, Cormier A, Tobaly-Tapiero J, Palmic N, Casartelli N, Mahboubi B, Coggins SA, Buchrieser J, Persaud M, Diaz-Griffero F, Espert L, Bossis G, Lesage P, Schwartz O, Kim B, Margottin-Goguet F, Saïb A, Zamborlini A. Martinat C, et al. Nat Commun. 2021 Jul 28;12(1):4582. doi: 10.1038/s41467-021-24802-5. Nat Commun. 2021. PMID: 34321470 Free PMC article.

4

Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.

Yu CH, Bhattacharya A, Persaud M, Taylor AB, Wang Z, Bulnes-Ramos A, Xu J, Selyutina A, Martinez-Lopez A, Cano K, Demeler B, Kim B, Hardies SC, Diaz-Griffero F, Ivanov DN. Yu CH, et al. Nat Commun. 2021 Feb 2;12(1):731. doi: 10.1038/s41467-021-21023-8. Nat Commun. 2021. PMID: 33531504 Free PMC article.

5

Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking viral protein X.

Coggins SA, Kim DH, Schinazi RF, Desrosier RC, Kim B. Coggins SA, et al. J Biol Chem. 2020 Dec 11;295(50):16975-16986. doi: 10.1074/jbc.RA120.015273. Epub 2020 Oct 2. J Biol Chem. 2020. PMID: 33008888 Free PMC article.

6

Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery.

Coggins SA, Mahboubi B, Schinazi RF, Kim B. Coggins SA, et al. J Biol Chem. 2020 Sep 25;295(39):13432-13443. doi: 10.1074/jbc.REV120.013746. Epub 2020 Jul 31. J Biol Chem. 2020. PMID: 32737197 Free PMC article. Review.

7

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer.

Gandhi M, Groß M, Holler JM, Coggins SA, Patil N, Leupold JH, Munschauer M, Schenone M, Hartigan CR, Allgayer H, Kim B, Diederichs S. Gandhi M, et al. Nat Commun. 2020 Jun 25;11(1):3214. doi: 10.1038/s41467-020-17007-9. Nat Commun. 2020. PMID: 32587247 Free PMC article.

8

Tetraspanin CD81 regulates HSV-1 infection.

Benayas B, Sastre I, López-Martín S, Oo A, Kim B, Bullido MJ, Aldudo J, Yáñez-Mó M. Benayas B, et al. Med Microbiol Immunol. 2020 Aug;209(4):489-498. doi: 10.1007/s00430-020-00684-0. Epub 2020 Jun 4. Med Microbiol Immunol. 2020. PMID: 32500359 Free PMC article.

9

Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine.

Balachander S, Gombolay AL, Yang T, Xu P, Newnam G, Keskin H, El-Sayed WMM, Bryksin AV, Tao S, Bowen NE, Schinazi RF, Kim B, Koh KD, Vannberg FO, Storici F. Balachander S, et al. Nat Commun. 2020 May 15;11(1):2447. doi: 10.1038/s41467-020-16152-5. Nat Commun. 2020. PMID: 32415081 Free PMC article.

10

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.

Rudd SG, Tsesmetzis N, Sanjiv K, Paulin CB, Sandhow L, Kutzner J, Hed Myrberg I, Bunten SS, Axelsson H, Zhang SM, Rasti A, Mäkelä P, Coggins SA, Tao S, Suman S, Branca RM, Mermelekas G, Wiita E, Lee S, Walfridsson J, Schinazi RF, Kim B, Lehtiö J, Rassidakis GZ, Pokrovskaja Tamm K, Warpman-Berglund U, Heyman M, Grandér D, Lehmann S, Lundbäck T, Qian H, Henter JI, Schaller T, Helleday T, Herold N. Rudd SG, et al. EMBO Mol Med. 2020 Mar 6;12(3):e10419. doi: 10.15252/emmm.201910419. Epub 2020 Jan 17. EMBO Mol Med. 2020. PMID: 31950591 Free PMC article.

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