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Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures.
Monastyrskyi A, Brockmeyer F, LaCrue AN, Zhao Y, Maher SP, Maignan JR, Padin-Irizarry V, Sakhno YI, Parvatkar PT, Asakawa AH, Huang L, Casandra D, Mashkouri S, Kyle DE, Manetsch R. Monastyrskyi A, et al. J Med Chem. 2021 May 27;64(10):6581-6595. doi: 10.1021/acs.jmedchem.0c01104. Epub 2021 May 12. J Med Chem. 2021. PMID: 33979164 Free PMC article.