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Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression.
Balasubramanian I, Bandyopadhyay S, Flores J, Bianchi-Smak J, Lin X, Liu H, Sun S, Golovchenko NB, Liu Y, Wang D, Patel R, Joseph I, Suntornsaratoon P, Vargas J, Green PH, Bhagat G, Lagana SM, Ying W, Zhang Y, Wang Z, Li WV, Singh S, Zhou Z, Kollias G, Farr LA, Moonah SN, Yu S, Wei Z, Bonder EM, Zhang L, Kiela PR, Edelblum KL, Ferraris R, Liu TC, Gao N. Balasubramanian I, et al. EMBO J. 2023 Nov 2;42(21):e113975. doi: 10.15252/embj.2023113975. Epub 2023 Sep 18. EMBO J. 2023. PMID: 37718683 Free PMC article.
A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis.
Yu X, Ma H, Li B, Ji Y, Du Y, Liu S, Li Z, Hao Y, Tian S, Zhao C, Du Q, Jin Z, Zhu X, Tian Y, Chen X, Sun X, Yang C, Zhu F, Ju J, Zheng Y, Zhang W, Wang J, Yang T, Wang X, Li J, Xu X, Du S, Lu H, Ma F, Zhang H, Zhang Y, Zhang X, Hu S, He S. Yu X, et al. Blood. 2023 Mar 2;141(9):1070-1086. doi: 10.1182/blood.2022017262. Blood. 2023. PMID: 36356302 Free PMC article.
Suppression of Ca2+ signaling enhances melanoma progression.
Gross S, Hooper R, Tomar D, Armstead AP, Shanas N, Mallu P, Joshi H, Ray S, Chong PL, Astsaturov I, Farma JM, Cai KQ, Chitrala KN, Elrod JW, Zaidi MR, Soboloff J. Gross S, et al. EMBO J. 2022 Oct 4;41(19):e110046. doi: 10.15252/embj.2021110046. Epub 2022 Aug 30. EMBO J. 2022. PMID: 36039850 Free PMC article.