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Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.
Cadinu P, Sivanathan KN, Misra A, Xu RJ, Mangani D, Yang E, Rone JM, Tooley K, Kye YC, Bod L, Geistlinger L, Lee T, Mertens RT, Ono N, Wang G, Sanmarco L, Quintana FJ, Anderson AC, Kuchroo VK, Moffitt JR, Nowarski R. Cadinu P, et al. Cell. 2024 Apr 11;187(8):2010-2028.e30. doi: 10.1016/j.cell.2024.03.013. Epub 2024 Apr 2. Cell. 2024. PMID: 38569542
Systems-based approaches to study immunometabolism.
Purohit V, Wagner A, Yosef N, Kuchroo VK. Purohit V, et al. Cell Mol Immunol. 2022 Mar;19(3):409-420. doi: 10.1038/s41423-021-00783-9. Epub 2022 Feb 4. Cell Mol Immunol. 2022. PMID: 35121805 Free PMC article. Review.
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function.
He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christian E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK. He D, et al. Immunity. 2022 Jan 11;55(1):159-173.e9. doi: 10.1016/j.immuni.2021.12.001. Epub 2022 Jan 3. Immunity. 2022. PMID: 34982959 Free PMC article.
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion.
Chen Z, Luo J, Li J, Kim G, Chen ES, Xiao S, Snapper SB, Bao B, An D, Blumberg RS, Lin CH, Wang S, Zhong J, Liu K, Li Q, Wu C, Kuchroo VK. Chen Z, et al. J Exp Med. 2021 Sep 6;218(9):e20210324. doi: 10.1084/jem.20210324. Epub 2021 Jul 21. J Exp Med. 2021. PMID: 34287641 Free PMC article.