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The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V. Xu M, et al. Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z. Nat Commun. 2024. PMID: 38467629 Free PMC article.
PPP2R2D suppresses IL-2 production and Treg function.
Pan W, Sharabi A, Ferretti A, Zhang Y, Burbano C, Yoshida N, Tsokos MG, Tsokos GC. Pan W, et al. JCI Insight. 2020 Oct 2;5(19):e138215. doi: 10.1172/jci.insight.138215. JCI Insight. 2020. PMID: 32897879 Free PMC article.
Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.
Rodríguez-Rodríguez N, Madera-Salcedo IK, Cisneros-Segura JA, García-González HB, Apostolidis SA, Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-Rodríguez DP, Tsokos GC, Alcocer-Varela J, Rosetti F, Crispín JC. Rodríguez-Rodríguez N, et al. J Clin Invest. 2020 Nov 2;130(11):5989-6004. doi: 10.1172/JCI129479. J Clin Invest. 2020. PMID: 32750040 Free PMC article.
Serine/threonine phosphatase PP2A is essential for optimal B cell function.
Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Meidan E, et al. JCI Insight. 2020 Mar 12;5(5):e130655. doi: 10.1172/jci.insight.130655. JCI Insight. 2020. PMID: 32161189 Free PMC article.