R01 AI135953/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R01 AI135953/AI/NIAID NIH HHS/United States[Grant - PubMed

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Year	Number of Results
2017	1
2018	1
2019	2
2020	5
2021	5
2022	2
2023	6
2024	0

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Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates.

Petty NE, Radtke S, Fields E, Humbert O, Llewellyn MJ, Laszlo GS, Zhu H, Jerome KR, Walter RB, Kiem HP. Petty NE, et al. Mol Ther Methods Clin Dev. 2023 Sep 26;31:101121. doi: 10.1016/j.omtm.2023.101121. eCollection 2023 Dec 14. Mol Ther Methods Clin Dev. 2023. PMID: 37868209 Free PMC article.

Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates.

Murray J, Einhaus T, Venkataraman R, Radtke S, Zhen A, Carrillo MA, Kitchen SG, Peterson CW, Kiem HP. Murray J, et al. Mol Ther Methods Clin Dev. 2023 Jul 18;30:276-287. doi: 10.1016/j.omtm.2023.07.006. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37575091 Free PMC article.

CD90-targeted lentiviral vectors for HSC gene therapy.

Berckmueller K, Thomas J, Taha EA, Choo S, Madhu R, Kanestrom G, Rupert PB, Strong R, Kiem HP, Radtke S. Berckmueller K, et al. Mol Ther. 2023 Oct 4;31(10):2901-2913. doi: 10.1016/j.ymthe.2023.08.003. Epub 2023 Aug 7. Mol Ther. 2023. PMID: 37550965

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation.

Radtke S, Enstrom M, Pande D, Duke ER, Cardozo-Ojeda EF, Madhu R, Owen S, Kanestrom G, Cui M, Perez AM, Schiffer JT, Kiem HP. Radtke S, et al. Blood. 2023 Jul 6;142(1):33-43. doi: 10.1182/blood.2022018564. Blood. 2023. PMID: 36821766

Safe and efficient lentiviral vector integration with HSC-targeted gene therapy.

Radtke S, Pande D, Enstrom M, Kiem HP. Radtke S, et al. Blood Adv. 2023 Sep 12;7(17):5132-5136. doi: 10.1182/bloodadvances.2022009087. Blood Adv. 2023. PMID: 36534128 Free PMC article. No abstract available.

Identification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Radtke S, Kiem HP. Radtke S, et al. Methods Mol Biol. 2023;2567:87-98. doi: 10.1007/978-1-0716-2679-5_6. Methods Mol Biol. 2023. PMID: 36255696

Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells.

El-Kharrag R, Berckmueller KE, Madhu R, Cui M, Campoy G, Mack HM, Wolf CB, Perez AM, Humbert O, Kiem HP, Radtke S. El-Kharrag R, et al. Mol Ther. 2022 Jun 1;30(6):2186-2198. doi: 10.1016/j.ymthe.2022.02.026. Epub 2022 Feb 28. Mol Ther. 2022. PMID: 35240320 Free PMC article.

Intracellular RNase activity dampens zinc finger nuclease-mediated gene editing in hematopoietic stem and progenitor cells.

Peterson CW, Venkataraman R, Reddy SS, Pande D, Enstrom MR, Radtke S, Humbert O, Kiem HP. Peterson CW, et al. Mol Ther Methods Clin Dev. 2021 Nov 22;24:30-39. doi: 10.1016/j.omtm.2021.11.010. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977270 Free PMC article.

Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.

Samuelson C, Radtke S, Zhu H, Llewellyn M, Fields E, Cook S, Huang MW, Jerome KR, Kiem HP, Humbert O. Samuelson C, et al. Mol Ther Methods Clin Dev. 2021 Oct 28;23:507-523. doi: 10.1016/j.omtm.2021.10.008. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34853798 Free PMC article.

Genome editing in large animal models.

Maynard LH, Humbert O, Peterson CW, Kiem HP. Maynard LH, et al. Mol Ther. 2021 Nov 3;29(11):3140-3152. doi: 10.1016/j.ymthe.2021.09.026. Epub 2021 Oct 1. Mol Ther. 2021. PMID: 34601132 Free PMC article. Review.

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